Titin folding powers muscle contraction Julio Fernandez, USA
Chair: Jorge Alegre-Cebollada, Spain
10:00-12:45
MECHANISMS OF MEMBRANE PROTEINS Chair:Antonio Ferrer, Spain and Elena Pohl, Austria Invited speakers: 10:00 Factors affecting Ion Permeation through K+-Channels Carmen Domene, UK 10:30 The first human lacking functional TRPV1 channel: Implications onTRPV1 functions in nociception. Baruk Minke, Israel
11:00-11:30 COFFEE BREAK
11:30 Optoelectrical dynamics of BK channel activation Teresa Giraldez, Spain
Short Talks: 12:00 Structural insight into TRPV5 channel function and modulation Jenny Van Der Wijst, Netherlands 12:15 Biophysical insights into membrane fission mediated by ESCRT-III Vasil Georgiev, Germany 12:30 Ion transport, interfacial effects and scaling behavior in protein channels Vicente Aguilella, Spain
MADRID
10:00-12:45
SINGLE MOLECULE BIOPHYSICS Chairs:Nuno Santos, Portugal and David Rueda, UK Invited speakers: 10:00 The mechanical stability of proteins regulates their translocation rate into the cell nucleus Sergi Garcia-Manyes, UK 10:30 Mechanosensitive states of the giant muscle protein titin Miklos Kellermayer, Hungary
11:00-11:30 COFFEE BREAK
11:30 Single-molecule live-cell imaging of mRNA life cycle María Carmo-Fonseca, UK
Short Talks: 12:00 ParB dynamics and the critical role of the C-terminal domain in DNA condensation unveiled by combined Magnetic Tweezers and TIRF Microscopy Julene Madariaga-Marcos, Spain 12:15 A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy Gabriel Zoldak, Slovakia 12:30 Single-molecule dissection of the dihydrofolate reductase reaction revealed multiple conformers leading to a catalytic product release Nicole Galenkamp, Netherlands
ROMA
10:00-12:45
BIOPHYSICS OF IMMUNE RESPONSE Chairs:Jean Marie Ruysschaert, Belgium and Mario Castro, Spain
Invited speakers: 10:00 Membrane Sensing and Remodelling during the immune synapse. A spatiotemporal adaptive tale of lipid packing dynamics and collective assembly Jorge Bernardino de la Serna, Spain 10:30 Mechanosensing via immunoreceptors Cheng Zhu, USA
11:00-11:30 COFFEE BREAK
11:30 The role of oligomeric scaffolds in inflammatory signal transduction through Toll-like receptors and MyD88 Nick Gay, UK
Short Talks: 12:00 Insights into the Molecular Mechanism of Lipids/Toll-Like Receptors Interaction Malvina Pizzuto, Spain 12:15 Super-resolution microscopy analysis of molecular interactions between epithelial cells and tissue-resident T cells in mouse epidermis Dmitry Ushakov, UK 12:30 Shape matters: Towards a molecular understanding of the innate immune response to microbial lipids Andra Schromm, Germany
