Programme

• 20 July 2019
• 21 July 2019
• 22 July 2019
• 23 July 2019
• 24 July 2019

• AUDITORIUM

  17:30	WELCOME ADDRESS
  18:00	PLENARY LECTURE Harnessing Evolution to create new medicines Sir Gregory Paul Winter Chair: Anthony Watts, UK

• • MORNING
  • AFTERNOON

  • AUDITORIUM

    09:00

    PLENARY LECTURE Eukaryotic organelles: deciphering their interdependency, structure and dynamics with new imaging technologies Jennifer Lippincott-Schwartz, USA Chair: María García-Parajo, Spain

    10:00-12:45

    PROTEIN FOLDING Chairs: Ana Azuaga, Spain and  Jacqueline Cherfils, France Invited speakers: 10:00 Understanding alpha-synuclein amyloid self-assembly and its associated toxicity Nunilo Cremades, Spain 10:30 Dodging the crisis of folding proteins with non-trivial topology - new challenges. Joanna Sulkowska, Powland 11:00-11:30 COFFEE BREAK 11:30 The structural determinants of the toxicity of misfolded protein oligomers associated with neurodegenerative diseases Fabrizio Chiti, Italy Short Talks: 12:00 Prion soft amyloid core driven self-assembly of globular proteins into bioactive nanofibrils Weiqiang Wang, Spain 12:15 Unravelling the details of the conformational cycle of the Hsp90 chaperone Katarzyna Tych, Germany 12:30 Strategically positioned slow codons support protein folding Michal Perach, Israel

    MADRID

    10:00-12:45

    DNA ARCHITECTURE AND GENE REGULATION Chairs: Masaki Sasai, Japan and Helmut Schiessel, Netherlands Invited speakers: 10:00 DNA release from histones in nucleosome core particles: measurements and models Lois Pollack, USA 10:30 Gene control with a “twist”: Exploring the dynamic chromatin landscape Beat Fierz, Switzerland 11:00-11:30 COFFEE BREAK 11:30 Chromosome organization in living human cells revealed by single nucleosome imaging Kazuhiro Maeshima, Japan Short Talks: 12:00 Non-specific action of polyamines leads to specific changes in structure and function of DNA Takashi Nishio, Japan 12:15 Simulating the binding of Pioneer Transcription Factors to the nucleosome Jan Huertas, Germany 12:30 Dependence of DNA Persistence Length on Ionic Strength and Ion Type Catherine Tardin, France

    ROMA

    10:00-12:45

    MECHANOBIOLOGY Chair: Pere Roca-Cusachs, Spain Invited speakers: 10:00 Mechanically and biochemically induced pathways regulating integrin-dependent cell adhesion Nico Strohmeyer, Switzerland 10:30 Molecular to cellular mechanics at short timescales Felix Rico, France 11:00-11:30 COFFEE BREAK 11:30 Mechanosensitive actomyosin network dynamics and migration plasticity in 3D environments Verena Ruprecht, Spain Short Talks: 12:00 Activation of human aortic valve interstitial cells by local stiffness in Calcific Aortic Valve Disease Loredana Casalis, Italy 12:15 Role of Rab8A and Caveolin-1 in the interplay between cell mechanotransduction and cholesterol trafficking Giulio Fulgoni, Spain 12:30 The Mechanical Work of Vinculin Binding to Talin Regulates Vinculin Activation Rafael Tapia Rojo, USA

    PARÍS

    10:00-12:45

    BIOPHYSICS OF CYTOSKELETON Chairs: Marisela Velez, Spain and Andreas Janshoff, Germany Invited speakers: 10:00 Mind the gap: polyampholytes meet the neuronal skeleton Roy Beck, Israel 10:30 Reconstitution of basic mitotic spindles in Cell-like confinement Marleen Dogterom, the Netherlands 11:00-11:30 COFFEE BREAK 11:30 The spindle is a composite of two permeating polar gels Jan Brugués, Germany Short Talks: 12:00 Structure dissection of a contractile phage tail tube Birgit Habenstein, France 12:15 Ultrafast tracking reveals the function of structural domains of single proteins Kristýna Holanová, Czech Republic 12:30 Nucleotide and Osmolyte Induced Folding of FtsZ from Staphylococcus aureus Sonia Huecas, Spain

    12:45-14:30

    LUNCH AND POSTER SESSION

  • AUDITORIUM

    14:30	PLENARY LECTURE Shaping Membranes with Proteins and Cytoskeleton: Deciphering Mechanisms with Reconstituted Systems Patricia Bassereau, France Chair: John Seddon, UK
    15:15	AVANTI-EBSA MEMBRANE BIOPHYSICS AWARD Chair: Anthony Watts, President EBSA Control of organelle dynamics by membrane curvature and lipid unsaturation Bruno Antonny, France
    16:00-16:30	EBSA YOUNG INVESTIGATOR AWARD Chair: Anthony Watts, President EBSA Sensing the matrix: transducing mechanical signals from integrins to the nucleus Pere Roca-Cusachs, Spain 16:30 – 17:00 COFFEE BREAK
    17:00-19:15	MEMBRANE STRUCTURE AND DYNAMICS Chairs: Claudia Steinem, Germany and Felix Goñi, Spain Invited speakers: 17:00 Lessons Learned from Complex Mimics of Biological Membranes Georg Pabst, Austria 17:30 Regulating the dynamic interactions between herpes simplex viruses and cell-surface glycosaminoglycans. Marta Bally, Sweden 18:00 IQGAP1 links phosphoinositide signaling to the cytoskeleton and promotes cytoskeletal reorganization Arne Gericke, USA Short Talks: 18:30 Adsorption kinetics of pulmonary surfactant complexes purified from bronchoalveolar lavages of porcine lungs and human amniotic fluid José Carlos Castillo-Sánchez, Spain 18:45 Microfluidic platforms for the handling, manipulation, and analysis of model cells Tom Robinson, Germany 19:00 Quantified Efficiency of Membrane Leakage Events Relates to Antimicrobial Selectivity Maria Hoernke, Germany

    MADRID

    17:00-19:15

    CELLULAR PROLIFERATION Chair: Juan M. R, Parrondo, Spain Invited speakers: 17:00 Dynamics of bacterial swarms and biofilms Knut Drescher, Germany 17:30 Biophysical Concepts Applied to Tumor Progression Herbert Levine, USA 18:00 How molecular forces shape bacterial biofilms Berenike Maier, Germany Short Talks: 18:30 A nonequilibrium phase transition theory for the formation of diverse homeostasis and the emergence of systematic aging in multicellular systems Yuting Lou, Japan 18:45 Molecular architecture of bacterial amyloids in Bacillus biofilms Nadia El Mammeri, France 19:00 Microviscosity of bacterial biofilm matrix characterized by fluorescence correlation spectroscopy and single particle tracking Valentin Dunsing, Germany

    ROMA

    17:00-19:15

    TRAFFICKING AND SIGNALLING Chairs: Ana Garcia-Saez, Germany and Carlo Manzo, Spain Invited speakers: 17:00 Systematic superresolution analysis of endocytosis reveals an actin nucleation nano-template that drives efficient vesicle formation Jonas Ries, Germany 17:30 Shedding new light on the nanoscale organization of GPCR signalling Davide Calebiro, UK 18:00 Cryo-EM structural analysis of focal adhesion machinery Naoko Mizuno, Germany Short Talks: 18:30 TANGO1 Regulates Membrane Tension to Mediate Collagen Export from the Endoplasmic Reticulum Felix Campelo, Spain 18:45 Facile membrane flow and tension equilibration at a presynaptic nerve terminal Erdem Karatekin, USA  19:00 Allosteric regulation of small GTPases at the surface of membranes Jacqueline Cherfils, France

    PARÍS

    17:00-19:15

    NON-EQUILIBRIUM PHYSICS Chairs: Udo Seifert, Germany Invited speakers: 17:00 How rotating ATP synthases can modulate membrane structure Ivan Lopez-Montero, Spain (Premio Enrique Pérez-Paya SBE ) 17:30 Quantifying and modelling active motion in biological systems Timo Betz, Germany 18:00 Dynamics of nanoparticle and virus uptake at cell membranes Ulrich Schwarz, Germany Short Talks: 18:30 Non-Equilibrium Processes in Proteins Triggered by Light: Excited States Molecular Dynamics Perspective Wieslaw Nowak, Poland 18:45 1/f noise in ion channels formed by the Classical Swine Fever Virus (CSFV) p7 protein Antonio Alcaraz, Spain 19:00 Biophysical models of mRNA translation applied to ribosome profiling data Juraj Szavits-Nossan, United Kingdom

• • MORNING
  • AFTERNOON

  • AUDITORIUM

    09:00

    PLENARY LECTURE Overcoming the multiscale simulation challenge for biomolecular systems Gregory Voth, USA Chair: Ilpo Vattulainen, Finland

    10:00-12:45

    BIOMOLECULAR SIMULATION I Chairs: Claudio Soares, Portugal and  Ilpo Vattulainen, Finland Invited speakers: 10:00 Deep learning for molecular biophysics Frank Noe, Germany 10:30 Sculpting cell membranes by protein nanomachines. Andela Saric, UK 11:00-11:30 COFFEE BREAK 11:30 Pentameric ligand-gated ion channels: new crystal structures and MD simulations Marc Delarue, France Short Talks: 12:00 Automated cryo-EM structure refinement using correlation-driven molecular dynamics Maxim Igaev, Germany 12:15 Aβ peptides and β-sheet breakers. A coarse grained molecular dynamics approach using GO-Martini Aishwarya Dhar, Italy 12:30 Effect of pH on the influenza fusion peptide structure and activity: A constant-pH molecular dynamics approach Diana Lousa, Portugal

    MADRID

    10:00-12:45

    MACROMOLECULAR COMPLEXES Chairs: Tony Wilkinson, UK and Irene Diaz-Moreno, Spain Invited speakers: 10:00 Recent insights into the peptide-loading complex machinery Simon Trowitzch, Germany 10:30 LUBAC and linear ubiquitin chains: novel tools to study immune signalling Katrin Rittinger, UK 11:00-11:30 COFFEE BREAK 11:30 Analysing cryoEM data quality in the post resolution revolution era: Validity criteria José M. Carazo, Spain Short Talks: 12:00 Histone tails in nucleosome: fuzzy interaction with DNA Sevastyan Rabdano, Russia 12:15 New protein-protein interaction modulators for the therapeutic regulation of synapse dysfunction in neurodevelopmental disorders and neurodegeneration Maria Jose Sanchez-Barrena, Spain 12:30 Structural characterisation of tissue-derived, disease-associated polymers of alpha-1-antitrypsin using conformation-selective antibodies and single-particle reconstructions from electron microscopy images James Irving, UK

    ROMA

    10:00-12:45

    BIOPHYSICS OF MEMBRANE OXIDATION Chairs: Manuel Prieto, Portugal and Rosangela Itri, Brazil Invited speakers: 10:00 Photosensitized oxidation of lipid membranes: yields and rates of chemical and physical changes Mauricio da Silva, Brazil 10:30 Achievements, challenges and hopes in the biophysical analysis of oxidised (phospho)lipids Ana Reis, Portugal 11:00-11:30 COFFEE BREAK 11:30 Oxysterols and Truncated Oxidized Phospholipids in Model Membranes Martin Hof, Czech Republic Short Talks: 12:00 Lipids as substrates and dynamic activators: pro-apoptotic lipid peroxidation at the mitochondrial membrane surface Patrick Van Der Wel, Netherlands 12:15 The effect of oxidised cholesterol on model red blood cell membranes Paul Smith, UK 12:30 Lipid curvature modulates function of mitochondrial membrane proteins Olga Jovanovic, Austria

    PARÍS

    10:00-12:45	EVOLUTIONARY DYNAMICS Chair: Susanna Manrubia, Spain Invited speakers: 10:00 Eco-evolutionary dynamics during Escherichia coli colonization of the mouse gut Isabel Gordo, Portugal 10:30 Evolutionary Biology of Cell Division: Integrating Quantitative Genetics and Cellular Biophysics Daniel Needelman, USA 11:00-11:30 COFFEE BREAK 11:30 Universal properties of genotype-phenotype maps Sebastian Ahnert, UK Short Talks: 12:00 ScarTrace: CRISPR/Cas9-mediated clonal tracing in zebrafish embryonic development and regeneration Anna Alemany,  The Netherlands (Premio Antalgenics SBE) 12:15 Rare beneficial mutations cannot halt Muller's ratchet in spatial populations Su-Chan Park, South Korea 12:30 Exploring phenotypic variability of bacteria using microfluidic cell traps Ágnes Ábrahám, Hungary
    12:45-14:30	LUNCH AND POSTER SESSION
    13:00-15:00	MEETING OF EBSA Presidents

  • AUDITORIUM

    15:00	PLENARY LECTURE (Biophysical Society Lecture) Cryo-EM to visualize structure and dynamics of complex biological macromolecular assemblies Eva Nogales, USA Chair: Jose Carrascosa, Madrid
    15:45	IUPAP Young Scientist Prize in Biological Physics 2019 Chair: Ramin Golestanian, Chair C6-IUPAP Bacterial collective behaviors Knut Drescher, Germany
    16:00	IUPAP Young Scientist Prize in Biological Physics 2018 Chair: Jeff Gore, USA, Vice-Chair Thermodynamics of biological active matter Nikta Fakhari, USA
    16:30-19:15	PROTEIN STRUCTURE AND FUNCTION Chairs: Mark Baldus, Netherlands and Juan Hermoso, Spain Invited speakers: 16:30 Unraveling the role of SepF in the early actinobacterial divisome Pedro Alzari, France 17:00 Molecular Basis for the Extra-Mitochondrial Roles of Cytochrome C in Cell Life and Death. Miguel Ángel de la Rosa, Spain 17:30 -18:00 COFFEE BREAK 18:00 Atomistic Simulation of Biomolecular Function: Ribosomal Translation and Ligand Binding Heterogeneity Helmut Grubmueller, Germany Short Talks: 18:30 Campylobacter jejuni Tlp3 dCache sensing domain specifically recognises hydrophobic amino acids Mohammad Firoz Khan, Australia 18:45 Dynamics of intrinsically disordered and unfolded proteins: investigations using neutron spin-echo spectroscopy Andreas Stadler, Germany 19:00 Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in the activation domain of a transcription factor Albert Escobedo, Spain

    MADRID

    16:30-19:15

    CELL MEMBRANE BIOPHYSICS (CPL Symposium) Chairs: Pierre Emmanuel Milhiet, France and Gemma Fabries, Spain Invited speakers: 16:30 Cholesterol modulation of nicotinic acetylcholine receptor single molecule and nanocluster trajectories Francisco Barrantes, Argentina 17:00 Morphology of Membrane Contact Sites Contributes to the Regulation of the Phosphatidylinositol Cycle Richard Epand, Canada 17:30-18:00 COFFEE BREAK 18:00 Redox lipidomics deciphers phospholipid signals of programmed cell death Valerian Kagan, USA Short Talks: 18:30 Linking Structure, Stability and Function in the Anti-Measles Virus Action of Tocopherol-Derivatized Peptide Nanoparticles Tiago N. Figueira, Portugal (Prize SBfP) 18:45 Antimicrobial Peptides Impair Bacteria Cell Structure Within Seconds Enrico F. Semeraro, Austria 19:00 Elucidating the nanoscale architecture of the plasma membrane with super-resolution spectroscopy Erdinc Sezgin, UK

    ROMA

    16:30-19:15

    NEW FRONTIERS IN BIOIMAGING Chairs: Silvia Caponi, Italy and Laszlo Matyus, Hungary              Invited speakers: 16:30 Faster and gentler optical nanoscopy for brain cell imaging Ilaria Testa, Sweden 17:00 The mesolens: a new instrument for 3d optical imaging of large biological specimens with sub-cellular resolution throughout Gail McConnell, UK 17:30-18:00 COFFEE BREAK 18:00 Brillouin Microscopy for cell and tissue biomechanics Giuliano Scarcelli, USA Short Talks: 18:30 Wavefront shaping for low background, high resolution STED-FCS in three dimensions Aurélien Barbotin, UK 18:45 High density single particle tracking reveals nano- and meso-scale dynamic organization of plasma membrane receptors in living cells Nicolas Mateos Estevez, Spain 19:00 Photophysics and engineering of transgene labels for optoacoustics Andre C. Stiel, Germany

    PARÍS

    16:30-19:15

    GENE NETWORK DYNAMICS AND SIGNALING Chairs: Marta Ibañez, Spain  Invited speakers: 16:30 Stochastic Turing patterns in the development of a one-dimensional organism Joel Stavans, Israel 17:00 Human time vs. Mouse time: in vitro segmentation clock as a model system Miki Ebisuya, Spain 17:30-18:00 COFFEE BREAK 18:00 Distinguishing dormant from dead by triggering life in spores Hyun Youk, Netherlands Short Talks: 18:30 Post-transcriptional regulation, noise and spatial transcript localization of small RNA-controlled genes in an Escherichia coli stress response network Rinat Arbel-Goren, Israel 18:45 Modeling cytoneme guidance for Hedgehog signaling Adrián Aguirre-Tamaral, Spain 19:00 Androgen receptor phosphorylation at Serine 96: influence on protein structure, function and interaction network Laura Tosatto, Italy

    19:15-20:15

    NATIONAL ASSEMBLIES

• • MORNING
  • AFTERNOON

  • AUDITORIUM

    09:00

    PLENARY LECTURE 6 Titin folding powers muscle contraction Julio Fernandez, USA Chair: Jorge Alegre-Cebollada, Spain

    10:00-12:45

    MECHANISMS OF MEMBRANE PROTEINS Chair: Antonio Ferrer, Spain and Elena Pohl, Austria Invited speakers: 10:00 Factors affecting Ion Permeation through K+-Channels Carmen Domene, UK 10:30 The first human lacking functional TRPV1 channel: Implications onTRPV1 functions in nociception. Baruk Minke, Israel 11:00-11:30 COFFEE BREAK 11:30 Optoelectrical dynamics of BK channel activation Teresa Giraldez, Spain Short Talks: 12:00 Structural insight into TRPV5 channel function and modulation Jenny Van Der Wijst, Netherlands 12:15 Biophysical insights into membrane fission mediated by ESCRT-III Vasil Georgiev, Germany 12:30 Ion transport, interfacial effects and scaling behavior in protein channels Vicente Aguilella, Spain

    MADRID

    10:00-12:45

    SINGLE MOLECULE BIOPHYSICS Chairs: Nuno Santos, Portugal and David Rueda, UK Invited speakers: 10:00 The mechanical stability of proteins regulates their translocation rate into the cell nucleus Sergi Garcia-Manyes, UK 10:30 Mechanosensitive states of the giant muscle protein titin Miklos Kellermayer, Hungary 11:00-11:30 COFFEE BREAK 11:30 Single-molecule live-cell imaging of mRNA life cycle María Carmo-Fonseca, UK Short Talks: 12:00 ParB dynamics and the critical role of the C-terminal domain in DNA condensation unveiled by combined Magnetic Tweezers and TIRF Microscopy Julene Madariaga-Marcos, Spain 12:15 A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy Gabriel Zoldak, Slovakia 12:30 Single-molecule dissection of the dihydrofolate reductase reaction revealed multiple conformers leading to a catalytic product release Nicole Galenkamp, Netherlands

    ROMA

    10:00-12:45

    BIOPHYSICS OF IMMUNE RESPONSE Chairs: Jean Marie Ruysschaert, Belgium and Mario Castro, Spain Invited speakers: 10:00 Membrane Sensing and Remodelling during the immune synapse. A spatiotemporal adaptive tale of lipid packing dynamics and collective assembly Jorge Bernardino de la Serna, Spain 10:30 Mechanosensing via immunoreceptors Cheng Zhu, USA 11:00-11:30 COFFEE BREAK 11:30 The role of oligomeric scaffolds in inflammatory signal transduction through Toll-like receptors and MyD88 Nick Gay, UK Short Talks: 12:00 Insights into the Molecular Mechanism of Lipids/Toll-Like Receptors Interaction Malvina Pizzuto, Spain 12:15 Super-resolution microscopy analysis of molecular interactions between epithelial cells and tissue-resident T cells in mouse epidermis Dmitry Ushakov, UK 12:30 Shape matters: Towards a molecular understanding of the innate immune response to microbial lipids Andra Schromm, Germany

    12:45-15:00

    LUNCH AND POSTER SESSION

  • AUDITORIUM

    15:00-16:15

    NEW AND NOTABLE Chairs: Anthony Watts, UK and Maria Garcia-Parajo, Spain 15:00 A molecular mechanism for transthyretin amyloidogenesis Trevor Forsyth, France 15:25 Cryo-EM of Helical Polymers at Near Atomic Resolution Yields Surprises: From Microbial Nanowires to Indestructible Pili. Edward H. Egelman, USA 15:50 To spread or not to spread: the mechanosensitive dilemma of T cells Kheya Senguptaa, France

    16:15-19:00

    BIOMOLECULAR SIMULATION II Chairs: Claudio Soares, Portugal and Ilpo Vattulainen, Finland Invited speakers: 16:15 Advances in Multiscale Simulation of DNA Modesto Orozco, Spain 16:45 Nanoparticle-bio interactions: the role of interface composition, conformation and softness Giulia Rossi, Italy 17:15-17:45 COFFEE BREAK 17:45 Lipid regulation of structure, dynamics, energetics, and function of membrane proteins Emad Tajkhorshid, USA Short Talks: 18:15 The catalytic mechanism of MB-COMT: new drug design paradigm? Alex Bunker, Finland 18:30 Combining theoretical and experimental approaches to understand the mechanism of antibiotic permeation: implications on the fight against bacterial resistance Carla F. Sousa, Portugal 18:45 Exploring Conformational Transitions and Free Energy Profiles of Proton Coupled oligopeptide Transport Mariana Batista, Brazil

    MADRID
    

    16:15-19:00

    LIVE IMAGING AND OPTICAL MICROSCOPY Chair: Susanne Fenz, Germany Invited speakers: 16:15 Faster and better: taking localisation microscopy into live cells Susan Cox, UK 16:45 A Multi Messenger microscope to paint chromatin in cell Alberto Diaspro, Italy 17:15-17:45 COFFEE BREAK 17:45 Looking into the nursery of platelets: Imaging of the bone marrow in vivo, in vitro and in silico Katrin Heinze, Germany Short Talks: 18:15 Strong cytoskeleton activity on millisecond timescales upon particle binding revealed by ROCS microscopy Felix Jünger, Germany 18:30 Multiplexed single-molecule fluorescence imaging by FRET-PAINT Nina Deußner-Helfmann, Germany 18:45 In vivo single-molecule imaging of DNA gyrase Ji-Eun Lee, UK

    ROMA

    16:15-19:00

    ACTIVE MATTER AND BIOLOGICAL SELF-ORGANIZATION Chairs: Ramin Golestanian, Germany Invited speakers: 16:15 ctive Polymers and Membranes Gerhard Gompper, Germany 16:45 The microtubule/kinesin system: A versatile realization of an active nematic Francesc Sagues, Spain 17:15-17:45 COFFEE BREAK 17:45 Spontaneous tension cable generation and convergence-extension flows in the gastrulating chick embryo Silke Henkes, UK Short Talks: 18:15 Design principles for robust self-assembly of multiple biological structures from limited resources Deb Sankar Banerjee, UK 18:30 Active phase separation in mixtures of chemically-interacting particles Jaime Agudo-Canalejo, UK 18:45 Self-organization of ciliary beats in bronchial epithelium Simon Gsell, France

    PARIS

    14:00-15:00	INFORMATION SESSION The European Research Council – Funding for frontier research in Europe Janne Salo, Finland , European Research Council Executive Agency Andela Šarić, UK, Starting grantee Cait MacPhee, UK,, Advanced Grant panel chair 2018
    16:15-19:00	IONIC LIQUIDS AND BIOMOLECULES Chairs: Hans-Joachim Galla, Germany and  Pietro Ballone, Ireland Invited speakers: 16:15 Ionic liquids in bio-systems: from model biomembranes to living cells Antonio Benedetto, Ireland 16:45 Aqueous Ionic Liquids: Consequences for Biological Stabilities Jens Smiatek, Germany 17:15-17:45 COFFEE BREAK 17:45 Studying fundamental role of ionic interactions to connect structure and properties of ionic liquids with biological activity Valentine Ananikov, Russia Short Talks: 18:15 Probing the effect of a room temperature ionic liquid on self-assembled structure of phospholipid membranes Saheli Mitra, India 18:30 The effect of imidazolium-based ionic liquids on human insulin aggregation/amyloid fibrillization Vladimir Vanik, Slovakia 18:45 Effect of Ionic Liquids on the Mechanoelasticity of Biomembranes: from Model Phospholipid Bilayers to Living Cells Pallavi Kumari, Ireland
    19:00-20:00	EBSA GENERAL ASSEMBLY

• • MORNING
  • AFTERNOON

  • AUDITORIUM

    09:00

    PLENARY LECTURE Nonequilibrium stresses and fluxes: compositional organization at the cell surface and organelle morphodynamics Madan Rao, India Chair: Juan M. R. Parrondo, Spain

    10:00-12:45

    LIPID AND LIPIDOME Chairs: John Seddon, UK and  Francisco Monroy, Spain Invited speakers: 10:00 Membrane remodeling by the amyloidogenic peptide IAPP: surface crowing relevance Manuel Prieto, Portugal 10:30 How the globoside Gb3 partitions in phase-separated membranes. Claudia Steinem, Germany 11:00-11:30 COFFEE BREAK 11:30 Curvature rigidity of asymmetric and differentially stressed membranes Markus Deserno, USA Short Talks: 12:00 Formation of membrane domains: insight from simulations on different scales Andreas Heuer, Germany 12:15 Monte Carlo and molecular dynamics simulations to explain biomembrane meso-patterning by a composition-curvature coupling mechanism Julie Cornet, France 12:30 Biophysical properties of 1-deoxyceramides in ordered and disordered bilayers Felix M Goñi, Spain

    MADRID

    10:00-12:45

    BIG DATA IN BIOPHYSICS Chairs: Remy Monasson, France and  Alfonso Valencia, Spain Invited speakers: 10:00 A systems approach to understanding the allosteric mechanism of pyruvate kinase M2 Franca Fraternali, UK 10:30 Statistical mechanics of protein evolution: From models to algorithms Ugo Bastolla, Spain 11:00-11:30 COFFEE BREAK 11:30 Combining imaging and gene expression data in mathematical models for immuno-oncology Vera Pancaldi, France Short Talks: 12:00 Real-time dynamic changes in serum metabolome during the anticancer treatment by means of NMR-based metabolomics Lukasz Boguszewicz, Poland 12:15 Decrypting interaction fingerprints in protein molecular surfaces Bruno Correia, Switzerland 12:30 Bayesian inference and machine learning approaches to determine protein copy number from localization microscopy Carlo Manzo, Spain

    ROMA

    10:00-12:45

    INSTRUCT-ERIC: INTEGRATING ACCESS TO BIOPHYSICS AND STRUCTURAL BIOLOGY IN EUROPE Chair: Ray Owens, UK Invited speakers: 10:00 Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity Rob Gilbert, UK 10:30 NMR-based hybrid approaches for cellular structural biology Marc Baldus, Netherlands 11:00-11:30 COFFEE BREAK 11:30 Towards High Throughput cryoEM data acquisition and processing, assuring reproducibility Jose-Maria Carazo, Spain Short Talks: 12:00 Access to structural biology and biophysics technologies through Instruct-ERIC Naomi Gray, UK 12:15 Crystal structures of bacteriophage receptor binding proteins Mark J. Van Raaij, Spain 12:30 The Cryo-EM Structure of a Non-toxic Greek Key Oligomer of Alpha Synuclein Ritobrita Chakraborty, India

    PARIS
    

    10:00-12:45	LIQUID-LIQUID PHASE SEPARATION IN BIOLOGICAL SYSTEMS Chair: Mauro della Serra, Italy Invited speakers: 10:00 Bacterial division protein phase-separated condensates: biochemical and functional consequences (Bruker SBE Prize) German Rivas, Spain 10:30 Light controlled cytoplasmic transport to probe cellular organization Mortiz Kreysing, Germany 11:00-11:30 COFFEE BREAK 11:30 Multivalency of proteins in cellular phase separation Samuel Safran, Israel Short Talks: 12:00 General sol to gel transition of liquid-liquid phase separated protein under shear Yi Shen, UK 12:15 Recapitulation of nucleocytoplasmic transport with phase-separation of engineered protein repeats Sheung Chun Ng, Germany 12:30 Protein phase transition: from biology towards new dynamic protein materials Paolo Arosio, Switzerland
    12:45-15:00	LUNCH AND POSTER SESSION
    14:00-15:00	EBSA EC SECOND MEETING

  • AUDITORIUM

    15:00-17:45

    MOLECULAR MOTORS Chairs: Christoph Schmidt, USA and José Carrascosa, Spain Invited speakers: 15:00 Cooperative Functions of Molecular Motor Assemblies Shin'Ichi Ishiwata, Japan 15:30 A molecular hurdle race: How does DNA polymerase deal with SSBs stably bound to the template? Borja Ibarra, Spain 16:00-16:30 COFFEE BREAK 16:30 A ratchet mechanism governs load adaptation by branched actin networks Peter Bieling, Germany Short Talks: 17:00 Kinesin-2 stepping reflects its heteromeric nature Willi L. Stepp, Germany 17:15 Reverse stroke of cardiac myosin revealed by single molecule microscopy is essential for heart function Yongtae Hwang, Japan 17:30 Artificial Assembly of the Bacterial Flagella Motor on DNA Scaffolds Sophie Hertel, Australia

    MADRID
    

    15:00-17:45

    TISSUE BIOPHYSICS AND MORPHOGENESIS Chair: Francoise Brochard-Wyart, France Invited speakers: 15:00 Forming, watching and stressing organoids Pierre Nassoy, France 15:30 Physics of epithelial folds and flows Guillaume Salbreux, UK 16:00-16:30 COFFEE BREAK 16:30 Bacterial colonies as active droplets - from single cells to continuum theory Vasily Zaburdaev, Germany Short Talks: 17:00 Biomimetic emulsions probe the mechanics of tissues Lea-Laetitia Pontani, France 17:15 Mechano-transduction and coordination of epithelial cells during Drosophila morphogenesis Matthias Häring, Germany 17:30 A hydraulic instability underlies oocyte size selection in C.elegans Arghyadip Mukherjee, Germany

    ROMA

    15:00-17:45

    EMERGING BREAKTHROUGH MOLECULAR-SCALE BIOPHYSICS METHODOLOGIES (ARBRE-MOBIEU COST Action) Chairs: Patrick England, France and Isabel Alves, France Invited speakers: 15:00 Adventures with dynamic and disordered systems Perdita Barran, UK 15:30 Access to Atomic Resolution Structural Information of Homo-Repeats: The Huntingtin Case Pau Bernado, France 16:00-16:30 COFFEE BREAK 16:30 Investigating the bacterial translocon at the single molecule level Peter Hinterdorfer, Austria Short Talks: 17:00 Correlative μ-Brillouin and μ-Raman spectroscopy: emerging tool for simultaneous mechanical and chemical analysis of cells and tissues Silvia Caponi, Italy 17:15 Revisiting the structure-function relationship with mass photometry Gavin Young, UK 17:30 Hierarchical micro- and nanostructured surface architectures for label-free spectroscopic and microscopic protein interrogation Julia Flesch, Germany

    AUDITORIUM
    

    18:00	CLOSING PLENARY LECTURE MINFLUX Nanoscopy: Superresolution post Nobel Stefan Hell, Germany Chair: Jesús Pérez-Gil, President (Elect) EBSA
    19:00	CLOSING CEREMONY
    21:00	CONGRESS DINNER